What levels of precision are achievable for quantification of perfusion and capillary permeability surface area product using ASL?

@article{Carr2007WhatLO,
  title={What levels of precision are achievable for quantification of perfusion and capillary permeability surface area product using ASL?},
  author={John P Carr and David L. Buckley and Jean J. L. Tessier and Geoffrey J. M. Parker},
  journal={Magnetic resonance in medicine},
  year={2007},
  volume={58 2},
  pages={281-9}
}
We examine the use of arterial spin labeling (ASL) in normal brains of rats and humans to measure perfusion (F) and capillary permeability surface area product (PS) using a previously described two-compartment model. We investigate the experimental limits on F and PS quantification using simulations and experimental verification in rat brain at 9.4T. A sensitivity analysis on the two-compartment model is presented to estimate optimal experimental inversion times (TIs) for F and PS… CONTINUE READING