What kinds of substrates show P-glycoprotein-dependent intestinal absorption? Comparison of verapamil with vinblastine.

@article{Ogihara2006WhatKO,
  title={What kinds of substrates show P-glycoprotein-dependent intestinal absorption? Comparison of verapamil with vinblastine.},
  author={Takuo Ogihara and Masatsugu Kamiya and Makoto Ozawa and Takuya Fujita and Akira Yamamoto and Shinji Yamashita and Shuhei Ohnishi and Yasuo Isomura},
  journal={Drug metabolism and pharmacokinetics},
  year={2006},
  volume={21 3},
  pages={
          238-44
        }
}
The influence of P-glycoprotein (P-gp) on intestinal absorption of drugs was investigated by comparison of the uptakes of two P-gp substrates, verapamil and vinblastine, using intestinal segments of wild-type and mdr1a/1b gene-deficient (mdr1a/1b(-/-)) mice, and Caco-2 cells. When [(3)H]vinblastine was injected into intestinal segments of wild-type mice, vinblastine was absorbed from duodenum and ileum, but not from jejunum. This difference among intestinal regions could not be explained by… CONTINUE READING
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