What is tibolone – and is it a SPEAR?

@article{Purdie2002WhatIT,
  title={What is tibolone – and is it a SPEAR?},
  author={D. Purdie},
  journal={Climacteric},
  year={2002},
  volume={5},
  pages={236 - 239}
}
A strange and remarkable beast is among us. Structurally, it is a steroid. Functionally, however, although there are five groupings of steroids, it would appear to belong to none. It is frequently classed, listed and described as a hormone replacement therapy (HRT) preparation, but it is not an estrogen. It has progestogenic and androgenic properties, yet is neither a progestogen nor an androgen, and nor, for good measure, is it a glucocorticoid or a mineralocorticoid. It is artificial in its… Expand
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Topics from this paper

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