What is the true risk of a pharmacokinetic drug–drug interaction?

@article{Fuhr2007WhatIT,
  title={What is the true risk of a pharmacokinetic drug–drug interaction?},
  author={Uwe Fuhr},
  journal={European Journal of Clinical Pharmacology},
  year={2007},
  volume={63},
  pages={897-899}
}
Reports on pharmacokinetic drug–drug interaction studies account for a major fraction of manuscripts in clinical pharmacology journals; this issue of European Journal of Clinical Pharmacology contains three of them [1–3]. Most of the published reports are positive, i.e. they show some degree of change in the pharmacokinetics of drug A when drug B is co-administered. A standard conclusion of such results is that great care should be applied if the two drugs are given concomitantly. In contrast… CONTINUE READING
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Guidance for Industry : Statistical Approaches to Establishing Bioequivalence

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