What is the threshold for a clinically relevant effect? The case of major depressive disorders.

@article{Cuijpers2014WhatIT,
  title={What is the threshold for a clinically relevant effect? The case of major depressive disorders.},
  author={Pim Cuijpers and Erick H. Turner and Sander L. Koole and Annemiek van Dijke and Filip Smit},
  journal={Depression and anxiety},
  year={2014},
  volume={31 5},
  pages={374-8}
}
BACKGROUND Randomized trials can show whether a treatment effect is statistically significant and can describe the size of the effect. There are, however, no validated methods available for establishing the clinical relevance of these outcomes. Recently, it was proposed that a standardized mean difference (SMD) of 0.50 be used as cutoff for clinical relevance in the treatment of depression. METHODS We explore what the effect size means and why the size of an effect has little bearing on its… CONTINUE READING