What is the role of the insulin-like growth factor system in the pathophysiology of cancer cachexia, and how is it regulated?

@article{Crown2002WhatIT,
  title={What is the role of the insulin-like growth factor system in the pathophysiology of cancer cachexia, and how is it regulated?},
  author={Anna L Crown and K Cottle and Stafford L. Lightman and Sandor Falk and Vidya Mohamed-Ali and Lynne V Armstrong and Ann B. Millar and Jeff M. P. Holly},
  journal={Clinical endocrinology},
  year={2002},
  volume={56 6},
  pages={723-33}
}
OBJECTIVE AND BACKGROUND The cancer cachexia syndrome is characterized by anorexia, weight loss with muscle wasting and increased energy expenditure. It is associated with increased morbidity and mortality, but its aetiology is poorly understood and no effective therapeutic intervention is available. It may result from an imbalance between the activity or effect of anabolic and catabolic hormones, mediated by the inflammatory cytokines. IGF-I is a potent anabolic agent, with therapeutic… CONTINUE READING