What is the role of protein aggregation in neurodegeneration?

@article{Ross2005WhatIT,
  title={What is the role of protein aggregation in neurodegeneration?},
  author={Christopher A. Ross and Michelle A. Poirier},
  journal={Nature Reviews Molecular Cell Biology},
  year={2005},
  volume={6},
  pages={891-898}
}
Neurodegenerative diseases typically involve deposits of inclusion bodies that contain abnormal aggregated proteins. Therefore, it has been suggested that protein aggregation is pathogenic. However, several lines of evidence indicate that inclusion bodies are not the main cause of toxicity, and probably represent a cellular protective response. Aggregation is a complex multi-step process of protein conformational change and accretion. The early species in this process might be most toxic… CONTINUE READING

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