What is the role of nitric oxide in murine and human host defense against tuberculosis?Current knowledge.

@article{Chan2001WhatIT,
  title={What is the role of nitric oxide in murine and human host defense against tuberculosis?Current knowledge.},
  author={Edward D. Chan and John Chan and Neil W Schluger},
  journal={American journal of respiratory cell and molecular biology},
  year={2001},
  volume={25 5},
  pages={606-12}
}
The production of reactive oxygen intermediates and reactive nitrogen intermediates by innate immune cells is considered to be an effective host-defense mechanism against microbial pathogens. In the murine model of tuberculosis (TB), nitric oxide (NO) plays an essential role in the killing of Mycobacterium tuberculosis by mononuclear phagocytes. For example, in the mouse strain with a genetic disruption for inducible NO synthase (iNOS-/-), infection with M. tuberculosis is associated with a… CONTINUE READING

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