What is the role of α-linolenic acid for mammals?

  title={What is the role of α-linolenic acid for mammals?},
  author={Andrew J E Sinclair and Nadia M. Attar-Bashi and Duo Li},
This review examines the data pertaining to an important and often underrated EFA, α-linolenic acid (ALA). It examines its sources, metabolism, and biological effects in various population studies, in vitro, animal, and human intervention studies. The main role of ALA was assumed to be as a precursor to the longer-chain n-3 PUFA, EPA and DHA, and particularly for supplying DHA for neural tissue. This paper reveals that the major metabolic route of ALA metabolism is β-oxidation. Furthermore, ALA… CONTINUE READING


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