What is the potential for overdiagnosis of heparin-induced thrombocytopenia?

@article{Lo2007WhatIT,
  title={What is the potential for overdiagnosis of heparin-induced thrombocytopenia?},
  author={Gregory K Lo and Christopher S Sigouin and Theodore E Warkentin},
  journal={American journal of hematology},
  year={2007},
  volume={82 12},
  pages={1037-43}
}
Heparin-induced thrombocytopenia (HIT) is caused by platelet-activating antibodies that recognize platelet factor 4//heparin (PF4/H) complexes. According to the "iceberg model," only a subset of anti-PF4/heparin antibodies of IgG class evincing strong platelet-activating properties cause clinical HIT. Since many centers rely predominantly on an anti-PF4/polyanion enzyme-immunoassay (EIA) to diagnose HIT, we estimated the potential for overdiagnosis when only this single test is available. We… CONTINUE READING