What is the pathophysiology of a hormone-resistant prostate tumour?

@article{Tombal2011WhatIT,
  title={What is the pathophysiology of a hormone-resistant prostate tumour?},
  author={Bertrand F Tombal},
  journal={European journal of cancer},
  year={2011},
  volume={47 Suppl 3},
  pages={
          S179-88
        }
}
Prostate cancer (PCa) is the most frequent cancer in males, and one of the leading causes of death by cancer. Despite majors advances in screening, early detection and local treatment, a large number of patients will progress to an advanced stage and require systemic treatment. Since the seminal work of Charles Huggins, androgen deprivation therapy (ADT), by means of orchiectomy or administration of oestrogens, has been the cornerstone treatment of advanced PCa [1]. Very early, however, Huggins… CONTINUE READING
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