What is the optimal dose and duration of treatment with etoposide? I. Maximum tolerated duration of daily treatment with 50, 75, and 100 mg of oral etoposide.

@article{Splinter1992WhatIT,
  title={What is the optimal dose and duration of treatment with etoposide? I. Maximum tolerated duration of daily treatment with 50, 75, and 100 mg of oral etoposide.},
  author={Ted A. W. Splinter and Ate van der Gaast and Tjebbe C Kok},
  journal={Seminars in oncology},
  year={1992},
  volume={19 6 Suppl 14},
  pages={1-7}
}
Because etoposide is a cell-cycle phase-specific drug, its degree of cytotoxicity likely relies on duration of cell exposure to a specific concentration. We investigated the maximum tolerated duration of oral etoposide treatment at doses of 100, 75, and 50 mg/d in previously treated patients with biopsy-proven, advanced cancer. "Maximum tolerated" was… CONTINUE READING