What is the mammalian dentate gyrus good for?

  title={What is the mammalian dentate gyrus good for?},
  author={Alessandro Treves and A. Tashiro and Menno P. Witter and Edvard I. Moser},

Figures from this paper

How Informative Are Spatial CA3 Representations Established by the Dentate Gyrus?

This work estimates the amount of information DG can impart on a new CA3 pattern of spatial activity, and indicates that even when DG codes just for space, much of the information it passes on to CA3 acquires a non-spatial and episodic character, akin to that of a random number generator.


The dentate gyrus is one subdivision of the mammalian hippocampus which has no clear correspondence in birds or reptiles, despite any superficial homology, and is thus at the same time the most striking component, within the structure in the authors' brain which is critical for memory formation, and the component most difficult to understand.

Pattern separation in the dentate gyrus: A role for the CA3 backprojection

A simple CA3 network model is considered, and it is hypothesize that CA3 backprojections might play an important role in hippocampal function, and shows that the DG‐CA3 model with backprojection provides a better fit to empirical data than a model without back projections.

Pattern separation in the hippocampus: distinct circuits under different conditions

It is argued for the case that sparse coding is necessary but not sufficient to ensure efficient separation and, alternatively, a possible interaction of distinct circuits which, nevertheless, act in synergy to produce a unitary function of pattern separation are proposed.

Spatial Cognition, Memory Capacity, and the Evolution of Mammalian Hippocampal Networks

It now appears, more clearly than before, that spatial computations per se are largely performed by the rat brain before the hippocampus is ever accessed, and culminate in a sort of universal map of allocentric space, in MEC layer II.

Distinct dendritic morphology across the blades of the rodent dentate gyrus

It is found that granule cells from the suprapyramidal blade of the DG contain greater dendritic material in the region receiving spatial information from the medial perforant path, providing a potential anatomical substrate for the asymmetric response of the dentate gyrus to spatial input.

Monosynaptic inputs to new neurons in the dentate gyrus.

The results show that newborn granule cells receive afferents from intra-hippocampal cells (interneurons, mossy cells, area CA3 and transiently, maturegranule cells) and septal cholinergic cells and PRH/LEC input is an important functional component of new dentate gyrus neuron circuitry.

Separation or binding? Role of the dentate gyrus in hippocampal mnemonic processing




Encoding and retrieval in the CA3 region of the hippocampus: a model of theta-phase separation.

A model of the CA3 subfield of the hippocampus is presented, using biophysical representations of the major cell types including pyramidal cells and two types of interneurons, and slow inhibitory neurons (O-LM cells) play a role in the disambiguation during retrieval.

Computational constraints suggest the need for two distinct input systems to the hippocampal CA3 network

The CA3 network in the hippocampus may operate as an autoassociator, in which declarative memories, known to be dependent on hippocampal processing, could be stored, and subsequently retrieved, using

Distinct short-term plasticity at two excitatory synapses in the hippocampus.

The results indicate that the mossy fiber synapse is able to integrate granule cell spiking activity over a broad range of frequencies, and this dynamic range is substantially reduced by long-term potentiation.

Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus

These results imply a dual mechanism for pattern separation in which signals from the entorhinal cortex can be decorrelated both by changes in coincidence patterns in the dentate gyrus and by recruitment of nonoverlapping cell assemblies in CA3.

A computational principle for hippocampal learning and neurogenesis

  • S. Becker
  • Biology, Computer Science
  • 2005
Simulations of the complete circuit confirm that both recognition memory and recall are superior relative to a hippocampally lesioned model, consistent with human data and support the prediction that memory capacity increases with the number of dentate granule cells, while neuronal turnover with a fixed dentate layer size improves recall.

Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network

Evidence is provided that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation, by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-d-aspartate (NMDA) receptor NR1 in dentates gyrus granule Cells.

Entorhinal cortex grid cells can map to hippocampal place cells by competitive learning

It is shown that the learning in the competitive network is an important part of the way in which the mapping of EC grid cells to dentate place cells is achieved and incorporation of a short term memory trace into the associative learning can help to produce the relatively broad place fields found in the hippocampus.

The fine structure of the mossy fibre endings in the hippocampus of the rabbit.

The site of termination of these fibres has been investigated with the electron microscope and where possible the results have been correlated with those of light microscopy.