What is the main mechanism of tramadol?

  title={What is the main mechanism of tramadol?},
  author={Kouichiro Minami and Junichi Ogata and Yasuhito Uezono},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
Tramadol is an analgesic that is used worldwide for pain, but its mechanisms of action have not been fully elucidated. The majority of studies to date have focused on activation of the μ-opioid receptor (μOR) and inhibition of monoamine reuptake as mechanisms of tramadol. Although it has been speculated that tramadol acts primarily through activation of the μOR, no evidence has revealed whether tramadol directly activates the μOR. During the past decade, major advances have been made in our… 
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  • E. Schembri
  • Biology, Medicine
    SN Comprehensive Clinical Medicine
  • 2018
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The Inhibitory Effects of Tramadol on Muscarinic Receptor-Induced Responses in Xenopus Oocytes Expressing Cloned M3 Receptors
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