What is the impact of coexistence of hepatolithiasis on cholangiocarcinoma?

@article{Lee2002WhatIT,
  title={What is the impact of coexistence of hepatolithiasis on cholangiocarcinoma?},
  author={Cheng-Chi Lee and Chun-Ying Wu and And Gran‐Hum Chen},
  journal={Journal of Gastroenterology and Hepatology},
  year={2002},
  volume={17}
}
Background: Hepatolithiasis is a well‐known etiology of cholangiocarcinoma. However, whether or not hepatolithiasis influences the presentation of cholangiocarcinoma is not very clear. To help clarify this, we conducted the present study to investigate the clinicopathological characteristics of cholangiocarcinoma with hepatolithiasis. As well, we made a comparison between the presence and absence of hepatolithiasis in patients with cholangiocarcinoma to determine the impact of hepatolithiasis. 
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44 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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44 Citations

Cholangiocarcinoma in a 24-year-old woman with hepatolithiasis.

A case of cholangiocarcinoma is presented in a 24-year-old woman who presented with the recurrent cholANGitis from hepatolithiasis who had multiple stones in an atrophic left lobe of the liver.

Endoscopic Evaluation and Management of Cholangiocarcinoma.

CT findings of cholangiocarcinoma associated with recurrent pyogenic cholangitis.

Cholangiocarcinoma associated with recurrent pyogenic cholangitis is predominantly located in the atrophic hepatic lobes and in the hepatic lobe of biliary calculi and is associated with the narrowing or obliteration of the portal vein.

Hepatolithiasis and intrahepatic cholangiocarcinoma: A review.

Surgical resection is recommended in cases of single lobe hepatolithiasis with atrophy, uncontrolled stricture, symptom duration of more than 10 years, and long history of biliary-enteric anastomosis, and it is not yet clear whether hepatic resection can reduce the occurrence of subsequent HL-CCA.

Hepatolithiasis-associated cholangiocarcinoma: results from a multi-institutional national database on a case series of 23 patients.

  • A. GuglielmiA. Ruzzenente C. Iacono
  • Medicine
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • 2014

Recurrent Pyogenic Cholangitis as an Unusual Indication for Liver Transplantation in a Center of a Western Country

Recurrent pyogenic cholangitis is a chronic infection characterized by intrahepatic biliary stones and strictures and two cases of RCP in Chinese patients treated with liver transplantation are reported.

Comparison of concomitant and subsequent cholangiocarcinomas associated with hepatolithiasis: Clinical implications.

C-CCA has better outcomes than S- CCA and the Kaplan-Meier curves corresponding to each group demonstrated better survival outcomes, and the rates of overall and disease-related mortality in both groups approached statistical significance.

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O Ongoing research efforts are focusing on the multifactorial contributions of environmental toxins, diet, obesity, and molecular mechanisms of CCA and GBCA development to improve early diagnosis and develop targeted therapies to complement surgical resection.

Cholangiocarcinoma

The etiology of this grave disease is unknown although many causative factors, including infectious, congenital, and genetic factors, causing chronic inflammation, which results in dysplastic changes of the biliary epithelium and eventual malignancy have been implicated.

Incidence and Prognosis of Subsequent Cholangiocarcinoma in Patients with Hepatic Resection for Bile Duct Stones

Subsequent CCA developed in 2% of the patients with hepatic resection for benign BDS until 10 years and was associated with poorer prognoses than concomitant CCA, and future studies focused on the long-term surveillance for CCA in such patients are needed.

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