Corpus ID: 34176053

What is the future of siRNA therapeutics

  title={What is the future of siRNA therapeutics},
  author={J. Lam and A. Worsley},
RNA interference (RNAi) – gene silencing by double-stranded RNA, is a Nobel Prize winning discovery by Fire and Mellow [1]. Since RNAi was found to occur in mammalian cells, it has been intensively investigated as a new therapeutic strategy. RNAi can be triggered by the introduction of synthetic sequence-specific small interfering RNA (siRNA), which is able to target and cleave complementary messenger RNA (mRNA) to achieve specific gene silencing. SiRNA is short double-stranded RNA molecule (21… Expand
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