What is the evidence for viscosupplementation in the treatment of patients with hip osteoarthritis? Systematic review of the literature

@article{Bekerom2007WhatIT,
  title={What is the evidence for viscosupplementation in the treatment of patients with hip osteoarthritis? Systematic review of the literature},
  author={Michel P. J. Bekerom and Bas Lamme and An Sermon and Michiel Mulier},
  journal={Archives of Orthopaedic and Trauma Surgery},
  year={2007},
  volume={128},
  pages={815-823}
}
IntroductionOsteoarthritis (OA) is a disease of the synovial joints and is the most common cause of chronic pain in the elderly. One of the treatment modalities for OA of the hip is viscosupplementation (VS). Today there are several different formulations of viscosupplements produced by different manufactures of different molecular weights. The objective of this review is to asses the efficacy of VS treatment of hip OA osteoarthritis in the current literature.Material and methodsThe following… 
When is indicated viscosupplementation in hip osteoarthritis?
Background and aim: The incidence of hip osteoarthritis (OA) is increasing in parallel with the aging of the population. The aim of this study is to report the efficacy of an ultrasound-guided
Viscosupplementation with Hyaluronic Acid in Hip Osteoarthritis (a review)
TLDR
The level of evidence was low in quite all the trials, and some questions still remain open : 1) the characteristics of responders must be more precisely defined; 2) the treatment schedules, at present mainly based on the individual clinical experience, need a proper and accepted standardization.
The evidence of surgery delay after viscosupplementation is increasing
TLDR
This review has evaluated several papers with data from administrative databases suggesting that viscosupplementation possesses the potential to delay or obviate the need for surgery in patients with knee or hip OA.
Optimizing the effectiveness of viscosupplementation in non-knee osteoarthritis.
  • T. Conrozier
  • Medicine
    Joint, bone, spine : revue du rhumatisme
  • 2016
TLDR
A closer look at these studies teaches a number of very nteresting lessons, which should help clinicians to make treatment ecisions and to participate in developing high-quality, large-scale, ontrolled studies with sufficiently long follow-ups.
Predictors of response to viscosupplementation in patients with hip osteoarthritis: results of a prospective, observational, multicentre, open-label, pilot study
TLDR
This pilot study suggests that radiological features might be of importance for the decision of VS in patients with hip osteoarthritis, and needs further confirmation by larger scale trials.
Consensus statement on viscosupplementation with hyaluronic acid for the management of osteoarthritis.
TLDR
A group of 8 experts in this field, from European countries, met to debate on 24 statements, and a consensus position has been proposed for each statement.
Hyaluronic Acid in the Treatment of Osteoarthritis: What is New
TLDR
Viscosupplementation by intra – articular injections of hyaluronic acid has been proposed as useful therapeutic option in the treatment of osteoarthritis in different joints and is summarized, reporting the recently published data and focusing attention on issues yet unsolved.
OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009.
OBJECTIVE To update evidence for available therapies in the treatment of hip and knee osteoarthritis (OA) and to examine whether research evidence has changed from 31 January 2006 to 31 January 2009.
Total hip replacement rate in a cohort of patients affected by symptomatic hip osteoarthritis following intra-articular sodium hyaluronate (MW 1,500–2,000 kDa) ORTOBRIX study
TLDR
Although further studies are necessary to confirm these data and to identify outcome predictors, hip viscosupplementation should be considered as conservative treatment to perform before proposing patients for THR in the real context of actual overall management of symptomatic hip OA patients.
Effect of hyaluronic acid in symptomatic hip osteoarthritis: a multicenter, randomized, placebo-controlled trial.
TLDR
The findings indicate that a single IA injection of hyaluronic acid is no more effective than placebo in treating the symptoms of hip OA.
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References

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Is there evidence to support the inclusion of viscosupplementation in the treatment paradigm for patients with hip osteoarthritis?
TLDR
In the absence of placebo-controlled studies, the efficacy of IA injections of HA or its derivatives in the symptomatic treatment of hip OA cannot be determined conclusively, but the published data suggest that viscosupplementation may be effective.
Viscosupplementation for the treatment of osteoarthritis of the knee.
TLDR
The pooled analyses of the effects of viscosupplementation against 'placebo' controls generally supported the efficacy of this class of intervention and readers should be cautious, therefore, in drawing conclusions regarding the relative value of different products.
Viscosupplementation for the treatment of osteoarthritis of the knee.
TLDR
The pooled analyses of the effects of viscosupplementation against 'placebo' controls generally supported the efficacy of this class of intervention and different efficacy effects were observed for different products on different variables and at different timepoints.
Intraarticular corticosteroid for treatment of osteoarthritis of the knee.
BACKGROUND Osteoarthritis (OA) is a common joint disorder. In the knee, injections of corticosteroids into the joint (intraarticular (IA)) may relieve inflammation, and reduce pain and disability.
Viscosupplementation in symptomatic severe hip osteoarthritis: a review of the literature and report on 60 patients.
TLDR
A literature review on the subject is presented and the results in 60 patients who received intraarticular viscosupplementation of the hip with the objective to delay total hip replacement surgery are reported.
Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis.
TLDR
It is suggested that the highest-molecular-weight hyaluronic acid may be more efficacious in treating knee OA, but heterogeneity of these studies limits definitive conclusions.
Comparison of the efficacy of lower and higher molecular weight viscosupplementation in the treatment of hip osteoarthritis
TLDR
Both types of viscosupplementation produced a significant clinical improvement during the 6-month follow-up period, however, no significant difference was found in outcomes between higher and lower molecular weight hyaluronan.
The symptomatic effects of intra-articular administration of hylan G-F 20 on osteoarthritis of the hip: clinical data of 6 months follow-up
TLDR
The present observation suggests the potentiality for the safety and efficacy of hylan G-F 20 injected under US guidance in patients with symptomatic hip OA, and further controlled studies are needed.
Open pilot study of ultrasound-guided intra-articular injection of hylan G-F 20 (Synvisc) in the treatment of symptomatic hip osteoarthritis
TLDR
The potential of ultrasound-guided intra-articular injections of a viscosupplement into the hip joint is demonstrated and positive preliminary information about the safety and efficacy of hylan G-F 20 for the treatment of symptomatic hip OA is given.
Intra-articular treatment of hip osteoarthritis: a randomized trial of hyaluronic acid, corticosteroid, and isotonic saline.
TLDR
Patients treated with corticosteroids experienced significant improvement during the 3 months of intervention, with an effect size indicating a moderate clinical effect, although a similar significant result following treatment with HA could not be shown.
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