What is the cause of retraction spaces associated with basal cell carcinoma?

To the Editor, Basal cell carcinoma (BCC) represents the most common skin cancer. Clefts (retraction spaces) or peritumoral lacunae are commonly observed at the periphery of the epithelial nests of BCC, and this morphological feature can be used as a diagnostic clue. However, the mechanism by which these peritumoral lacunae originate remains to be… CONTINUE READING