What is proton pump inhibitors unresponsiveness in gastroesophageal reflux disease? How should these cases be managed?

@article{elebi2017WhatIP,
  title={What is proton pump inhibitors unresponsiveness in gastroesophageal reflux disease? How should these cases be managed?},
  author={Ahmet Kemal Çelebi and Hasan Ali Yılmaz},
  journal={The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology},
  year={2017},
  volume={28 Suppl 1},
  pages={
          S71-S72
        }
}
Proton pump inhibitors become the most potent therapeutic option in gastroesophageal reflux disease. Unresponsiveness to this treatment is not uncommon in clinical practice. We reviewed the definition of PPI unresponsiveness and the management of this situation. 

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