What is physiologic complexity and how does it change with aging and disease?

@article{Goldberger2002WhatIP,
  title={What is physiologic complexity and how does it change with aging and disease?},
  author={A. Goldberger and C. Peng and L. Lipsitz},
  journal={Neurobiology of Aging},
  year={2002},
  volume={23},
  pages={23-26}
}
1. IntroductionA defining but elusive feature of physiologic systems istheir daunting complexity. This complexity arises from theinteraction of a myriad of structural units and regulatoryfeedback loops that operate over a wide range of temporaland spatial scales, enabling the organism to adapt to thestresses of everyday life. Quantifying and modeling theremarkable and often bewildering repertoire of behaviorsexhibited by living organisms is one of the major challengesof contemporary science [4,7… Expand

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