What is modulating solubility in simulated intestinal fluids?

@article{Ottaviani2010WhatIM,
  title={What is modulating solubility in simulated intestinal fluids?},
  author={Giorgio Ottaviani and Daniel J Gosling and Celine Patissier and Stephane Rodde and Liping X Zhou and Bernard Faller},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2010},
  volume={41 3-4},
  pages={452-7}
}
The aim of this study was to understand which parameters are responsible for the selective modulation of compounds solubility in simulated intestinal fluids. The solubility of 25 chemically diverse reference compounds was measured in simulated intestinal fluid (FaSSIF-V2) and in aqueous phosphate and maleate buffers. Electrostatic interactions between compounds and the bio-relevant medium components seem to explain the different solubility behavior observed for acids and bases. The solubility… CONTINUE READING

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