What is in a number? The FDG lumped constant in the rat brain.

  title={What is in a number? The FDG lumped constant in the rat brain.},
  author={Kenneth A. Krohn and Mark Muzi and Alexander M. Spence},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={48 1},
PET with 18F-FDG is being used in humans to study regional brain metabolism in normal and disease states. The underpinning of this approach is that FDG, like glucose, is transported across the blood–brain barrier and phosphorylated by hexokinase to FDG-6-phosphate, which accumulates in the tissue at a rate proportional to the rate of glucose use. However, because FDG and glucose differ in their rates of transport and phosphorylation and respective volumes of distribution (VDs) in brain tissue… CONTINUE READING

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