What is clinically meaningful: outcome measures in pain clinical trials.

@article{Farrar2000WhatIC,
  title={What is clinically meaningful: outcome measures in pain clinical trials.},
  author={John Thruston Farrar},
  journal={The Clinical journal of pain},
  year={2000},
  volume={16 2 Suppl},
  pages={S106-12}
}
OBJECTIVE The goal of this analysis is a better understanding of the issues involved in establishing the amount of change in pain that must be reported by subjects, participating in clinical trials and using standard pain scales, to indicate a clinically important difference. DESIGN A review of the literature and a discussion of relevant concepts are presented. The focus is on outcome measures of pain commonly used in the studies described, including pain intensity, pain relief, global… CONTINUE READING

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