What is an appropriate measure of exposure when testing drugs for carcinogenicity in rodents?

@article{Monro1992WhatIA,
  title={What is an appropriate measure of exposure when testing drugs for carcinogenicity in rodents?},
  author={Alastair M. Monro},
  journal={Toxicology and applied pharmacology},
  year={1992},
  volume={112 2},
  pages={171-81}
}
This discussion paper argues that in the carcinogenicity testing of drugs, biological measures of drug exposure may often be more relevant than the classical pharmacokinetic approaches applicable to reversible pharmacodynamic phenomena. Chemicals that produce tumors in rodents may do so (either directly or after bioactivation) by mechanisms involving inter alia a mutagenic, cytotoxic, or hormone-like effect. Such mechanisms may involve the formation of reactive metabolites of fleeting existence… CONTINUE READING

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