What investigators need to know about the use of animals.

@article{Silk2014WhatIN,
  title={What investigators need to know about the use of animals.},
  author={Susan Brust Silk and Lori L Hampton and Patricia A. Brown},
  journal={ILAR journal},
  year={2014},
  volume={54 3},
  pages={
          324-8
        }
}
Investigators conducting research with animal subjects have an ethical and legal responsibility to ensure they are treated humanely. The system of animal research oversight in the United States consists of a framework of federal, state, local, and institutional requirements. Institutions supported by the Public Health Service (PHS) are required to follow the guidelines mandated by the PHS Policy on Humane Care and Use of Laboratory Animals and establish institutional animal care and use… 

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References

SHOWING 1-10 OF 24 REFERENCES

International Guiding Principles for Biomedical Research Involving Animals

  • 笠井 憲雪
  • Medicine
    Alternatives to laboratory animals : ATLA
  • 1985
The guiding principles proposed here provide a framework for more specific national or institutional provisions on the use of animals for research, testing, or training in different countries.

The Guide for the Care and Use of Laboratory Animals.

While all studies should employ endpoints that are humane, studies that commonly require special consideration include those that involve tumor models, infectious diseases, vaccine challenge, pain modeling, trauma, production of monoclonal antibodies, assessment of toxicologic effects, organ or system failure, and models of cardiovascular shock.

Frequently asked questions about bed bugs

Bed bugs are insects that feed on the blood of people and animals. They are small, flat, brown, and oval. They do not have wings. • Bed bug eggs are white and pear-shaped. When they first hatch, bed

Grants Policy Statement; Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General

  • 4.1.1.5 Reporting to OLAW. Avail­ able online (http://grants.nih.gov/grants/policy/nihgps_2012/ nihgps_ch4.htm#olaw_reporting), last accessed June 3, 2013.
  • 2012

What Investigators Need to Know About the Use of Animals Available at (http://grants.nih.gov/grants/olaw/InvestigatorsNeed2Know. pdf), last accessed

  • What Investigators Need to Know About the Use of Animals Available at (http://grants.nih.gov/grants/olaw/InvestigatorsNeed2Know. pdf), last accessed
  • 2006

Disaster Planning and Response Resources Available online (http://grants.nih.gov/grants/olaw/disaster_planning.htm), last accessed

  • Disaster Planning and Response Resources Available online (http://grants.nih.gov/grants/olaw/disaster_planning.htm), last accessed
  • 2013

NIH Animal Awareness Poster. Good Animal Care and Good Science Go Hand in Hand Available online

  • NIH Animal Awareness Poster. Good Animal Care and Good Science Go Hand in Hand Available online
  • 2013

Medical Research with Animals, for Researchers and Institu­ tions, How NIH Can Help Available online (http://grants.nih.gov/ grants/policy/air/preparedness_help.htm), last accessed

  • Medical Research with Animals, for Researchers and Institu­ tions, How NIH Can Help Available online (http://grants.nih.gov/ grants/policy/air/preparedness_help.htm), last accessed
  • 2013