What hope for the future? GNAQ and uveal melanoma.

  title={What hope for the future? GNAQ and uveal melanoma.},
  author={Karen Sisley and Rachel P Doherty and Neil Alan Cross},
  journal={The British journal of ophthalmology},
  volume={95 5},
Uveal melanomas (UM) are aggressive ocular tumours that spread to the liver. They are characterised by alterations of chromosome 3 and 8, which are highly predictive of a poor prognosis. Unfortunately, being able to identify those patients with aggressive disease has not, as yet, translated into improved survival. Recently, mutations of guanine nucleotide-binding protein G(q) subunit alpha (GNAQ, or G-alpha-q), which effectively turn it into a dominantly acting oncogene, have been identified in… CONTINUE READING