What history tells us XXXVII. CRISPR-Cas: The discovery of an immune system in prokaryotes

  title={What history tells us XXXVII. CRISPR-Cas: The discovery of an immune system in prokaryotes},
  author={Michel Morange},
  journal={Journal of Biosciences},
  • M. Morange
  • Published 3 May 2015
  • Biology
  • Journal of Biosciences
The discovery of the CRISPR-Cas9 system of genome editing was the result of an explosive encounter between two different programs of research. One was the study of an ensemble of genomic sequences (CRISPR) present in eubacteria and archaea, the functions of which were totally ignored. The first historical descriptions that have been given of the discovery that these sequences were an immune system of bacteria mention three articles published in 2005 that showed through bioinformatic approaches… 

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  • M. Morange
  • Philosophy
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  • 2017
It is shown that for plenty of reasons, both scientific and societal, germline modification is no longer a priority for the authors' societies.



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