What history tells us XIX. The notion of the episome

@article{Morange2009WhatHT,
  title={What history tells us XIX. The notion of the episome},
  author={Michel Morange},
  journal={Journal of Biosciences},
  year={2009},
  volume={34},
  pages={845-848}
}
  • M. Morange
  • Published 30 November 2009
  • Biology
  • Journal of Biosciences
Modern textbooks of biology and molecular biology describe episomes only briefl y or not at all. Plasmids receive much more attention. The notion of episome was fi rst introduced in a publication of the French Academy of Science by François Jacob and Elie Wollman in 1958 (Jacob and Wollman 1958): episomes “may or may not be present in a cell, and when present they may be either autonomous or integrated” (in the chromosome) (Jacob and Wollman 1958). Episomes were more precisely described in… 

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The replicon model was a first and significant step from molecular biology to molecular cell biology, as well as a decisive moment in the scientific career of Jacob and was deeply anchored in the previous work of the Pasteurian group.

History of science is good for you

The editorial raises a tremendously important issue — namely the relevance of science’s past for its present productivity — but in the opinion it narrows the problem to one of accessing publications in the digital age, and encourages microbiologists to engage more extensively with historical literature.

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