What have snakes taught us about integrins?

  title={What have snakes taught us about integrins?},
  author={T. C. Huang},
  journal={Cellular and Molecular Life Sciences CMLS},
Snake venoms contain unique components that affect cell-matrix interactions. Disintegrins represent a class of low molecular weight, Arg-Gly-Asp (RGD)-containing, cysteine-rich peptides purified from the venom of various snakes among the Viperidae and Crotalidae. They bind with various degrees of specificity to integrins α IIb  β 3 , α 5  β 1 and α V  β 3 expressed on cells. Snake venom metalloproteases (high molecular mass haemorrhagins) also contain disintegrin-like domains, in addition to… CONTINUE READING


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