What has DNA sequencing revealed about the VSG expression sites of African trypanosomes?

@article{McCulloch2009WhatHD,
  title={What has DNA sequencing revealed about the VSG expression sites of African trypanosomes?},
  author={Richard McCulloch and David Horn},
  journal={Trends in parasitology},
  year={2009},
  volume={25 8},
  pages={359-63}
}
Antigenic variation is crucial for the survival of African trypanosomes in mammals and involves switches in expression of variant surface glycoprotein genes, which are co-transcribed with a number of expression-site-associated genes (ESAGs) from loci termed 'bloodstream expression sites' (BESs). Trypanosomes possess multiple BESs, although the reason for this (and why ESAGs are resident in these loci) has remained a subject of debate. The genome sequence of Trypanosoma brucei, released in 2005… CONTINUE READING

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A yeastendonucleasegenerated DNA break induces antigenic switching in Trypanosoma brucei

D. F. Cully
Nature • 2009

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