What does it take to make the perfect clot?

  title={What does it take to make the perfect clot?},
  author={Dougald M Monroe and M. Hoffman},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={26 1},
The coagulation process has been conceptualized as being primarily dependent on adequate levels of the coagulation proteins. This concept was based on the clear relationship between the bleeding tendency and factor levels in hemophilia. The field is now evolving toward conceptualizing coagulation as being actively regulated by the specialized cellular components of the process. Rather than conceiving coagulation as only a "cascade" of proteolytic reactions, the coagulation reactions occur as… CONTINUE READING
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