What does it mean to be natively unfolded?

@article{Uversky2002WhatDI,
  title={What does it mean to be natively unfolded?},
  author={Vladimir N. Uversky},
  journal={European journal of biochemistry},
  year={2002},
  volume={269 1},
  pages={
          2-12
        }
}
Natively unfolded or intrinsically unstructured proteins constitute a unique group of the protein kingdom. The evolutionary persistence of such proteins represents strong evidence in the favor of their importance and raises intriguing questions about the role of protein disorders in biological processes. Additionally, natively unfolded proteins, with their lack of ordered structure, represent attractive targets for the biophysical studies of the unfolded polypeptide chain under physiological… CONTINUE READING
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