What does Mos do in oocytes and somatic cells?

  title={What does Mos do in oocytes and somatic cells?},
  author={Noriyuki Sagata},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={19 1},
  • Noriyuki Sagata
  • Published 1997 in
    BioEssays : news and reviews in molecular…
Mos, a protein kinase, is specifically expressed and functions during meiotic maturation (or G2/M progression) of vertebrate oocytes. When expressed ectopically, however, it can also readily induce oncogenic transformation (or uncontrolled G1/S transitions) in somatic cells. In both of these cell types, Mos activates mitogen-activated protein kinase (MAPK), which seems largely to mediate its different functions in both oocyte maturation and cellular transformation. In oocyte maturation, the Mos… CONTINUE READING

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