What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?

Abstract

Studies of many different rodent models of muscle wasting have indicated that accelerated proteolysis via the ubiquitin-proteasome pathway is the principal cause of muscle atrophy induced by fasting, cancer cachexia, metabolic acidosis, denervation, disuse, diabetes, sepsis, burns, hyperthyroidism and excess glucocorticoids. However, our understanding about… (More)

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@article{Jagoe2001WhatDW, title={What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?}, author={Roger Jagoe and Alfred L Goldberg}, journal={Current opinion in clinical nutrition and metabolic care}, year={2001}, volume={4 3}, pages={183-90} }