What do we know about the genetics of aspirin intolerance?

@article{Palikhe2008WhatDW,
  title={What do we know about the genetics of aspirin intolerance?},
  author={Nami Shrestha Palikhe and Shin-Hee Kim and Hyungbin Park},
  journal={Journal of clinical pharmacy and therapeutics},
  year={2008},
  volume={33 5},
  pages={465-72}
}
Although acetylsalicylic acid is prescribed for a broad range of diseases, it can induce a wide array of clinically recognized hypersensitivity reactions, including aspirin-intolerant asthma (AIA) with rhinitis and aspirin-intolerant urticaria (AIU) with anaphylaxis. Altered eicosanoid metabolism is the generally accepted mechanism of aspirin intolerance; the overproduction of cysteinyl leucotrienes has been suggested to play a causative role in both AIA and AIU. Genetic markers suggested for… CONTINUE READING

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