What do we know about the genetics of aspirin intolerance?

  title={What do we know about the genetics of aspirin intolerance?},
  author={Nami Shrestha Palikhe and Shin-Hee Kim and Hyungbin Park},
  journal={Journal of clinical pharmacy and therapeutics},
  volume={33 5},
Although acetylsalicylic acid is prescribed for a broad range of diseases, it can induce a wide array of clinically recognized hypersensitivity reactions, including aspirin-intolerant asthma (AIA) with rhinitis and aspirin-intolerant urticaria (AIU) with anaphylaxis. Altered eicosanoid metabolism is the generally accepted mechanism of aspirin intolerance; the overproduction of cysteinyl leucotrienes has been suggested to play a causative role in both AIA and AIU. Genetic markers suggested for… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 20 extracted citations

Syntropic genes of allergic diseases

Russian Journal of Genetics • 2010
View 12 Excerpts
Highly Influenced

PGX: Pharmacogenomics During Generation X.

Advances in chronic kidney disease • 2016

Aspirin desensitisation for Chinese patients with coronary artery disease.

Hong Kong medical journal = Xianggang yi xue za zhi • 2013


Publications referenced by this paper.
Showing 1-10 of 45 references

Association between chronic urticaria and thyroid autoimmunity.

European journal of dermatology : EJD • 2006
View 1 Excerpt

Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology • 2006
View 1 Excerpt

Similar Papers

Loading similar papers…