What can long-lived mutants tell us about mechanisms causing aging and lifespan variation in natural environments?

Abstract

Long-lived mutants of model organisms have brought remarkable progress in our understanding of aging mechanisms. However, long-lived mutants are usually maintained in optimal standardized laboratory environments (SLEs), and it is not obvious to what extent insights from long-lived mutants in SLEs can be generalized to more natural environments. To address… (More)
DOI: 10.1016/j.exger.2015.09.002

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