What can humans learn from flies about adenomatous polyposis coli?

@article{Barth2002WhatCH,
  title={What can humans learn from flies about adenomatous polyposis coli?},
  author={Angela I. M. Barth and W. James Nelson},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2002},
  volume={24 9},
  pages={771-4}
}
Somatic or inherited mutations in the adenomatous polyposis coli (APC) gene are a frequent cause of colorectal cancer in humans. APC protein has an important tumor suppression function to reduce cellular levels of the signaling protein beta-catenin and, thereby, inhibit beta-catenin and T-cell-factor-mediated gene expression. In addition, APC protein binds to microtubules in vertebrate cells and localizes to actin-rich adherens junctions in epithelial cells of the fruit fly Drosophila (Fig. 1… CONTINUE READING