What can go wrong when ignoring correlation bounds in the use of generalized estimating equations.

@article{Sabo2010WhatCG,
  title={What can go wrong when ignoring correlation bounds in the use of generalized estimating equations.},
  author={Roy T. Sabo and N. Rao Chaganty},
  journal={Statistics in medicine},
  year={2010},
  volume={29 24},
  pages={2501-7}
}
The analysis of repeated measure or clustered data is often complicated by the presence of correlation. Further complications arise for discrete responses, where the marginal probability-dependent Fréchet bounds impose feasibility limits on the correlation that are often more restrictive than the positive definite range. Some popular statistical methods, such as generalized estimating equations (GEE), ignore these bounds, and as such can generate erroneous estimates and lead to incorrect… CONTINUE READING