What can SV40-derived vectors do for gene therapy?

  title={What can SV40-derived vectors do for gene therapy?},
  author={David S. Strayer and Mark A. Zern and Jayanta Roy Chowdhury},
  journal={Current opinion in molecular therapeutics},
  volume={4 4},
The limited success of gene therapy as an approach to treating human disease largely reflects the limitations of the gene delivery vectors that have been used. Poor titers, low transduction efficiency, waning transgene expression and immunogenicity have remained obstacles in the field. As a consequence, much research in normal, immunocompetent animals has not demonstrated therapeutic levels of gene delivery, and results from most human clinical trials have been predictably discouraging… CONTINUE READING

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