What are the physiological estrogens?

  title={What are the physiological estrogens?},
  author={M. Baker},
  • M. Baker
  • Published 2013
  • Chemistry, Medicine
  • Steroids
  • Estradiol (E2) is the principal physiological estrogen in mammals. E2 and its active metabolites, estrone and estriol have a characteristic phenolic A ring, unlike progesterone, testosterone, cortisol and aldosterone, which have an A ring containing a C3-ketone, a Δ(4) bond and a C19 methyl group. Crystal structures of E2 in the estrogen receptor (ER) confirm the importance of the A ring in stabilizing E2 in the ER. However, other steroids, including Δ(5)-androstenediol, 5α-androstanediol and… CONTINUE READING
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