What are the macrophages and stellate cells doing in pancreatic adenocarcinoma?

Abstract

Pancreatic ductal adenocarcinoma is a devastating disease characterized by a dense desmoplastic stroma. Chemo- and radio-therapeutic strategies based on targeting cancer cells have failed in improving the outcome of this cancer suggesting important roles for stroma in therapy resistance. Cells in the tumor stroma have been shown to regulate proliferation… (More)
DOI: 10.3389/fphys.2015.00125

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