What are the ‘ideal’ features of an adrenaline (epinephrine) auto‐injector in the treatment of anaphylaxis?

@article{Frew2011WhatAT,
  title={What are the ‘ideal’ features of an adrenaline (epinephrine) auto‐injector in the treatment of anaphylaxis?},
  author={Anthony J. Frew},
  journal={Allergy},
  year={2011},
  volume={66}
}
  • A. Frew
  • Published 1 January 2011
  • Medicine
  • Allergy
To cite this article: Frew A.J. What are the ‘ideal’ features of an adrenaline (epinephrine) auto‐injector in the treatment of anaphylaxis? Allergy 2011; 66: 15–24. 
Epinephrine auto‐injector use in adolescents at risk of anaphylaxis: a qualitative study in Scotland, UK
Cite this as: M. Gallagher, A. Worth, S. Cunningham‐Burley and A. Sheikh, Clinical & Experimental Allergy, 2011 (41) 869–877.
Epinephrine Auto-Injector Pandemic
TLDR
An overview of the increasing number of epinephrine auto-injector prescriptions and the underlying causes and contributing factors to these rising prescriptions is provided.
Make‐up of the epinephrine autoinjector: the effect on its use by untrained users
TLDR
Make‐up of the epinephrine autoinjector affects the effect on its use by untrained users, according to research published in Pediatric Allergy Immunology 2011.
Self-Injectable Adrenaline for Anaphylactic Emergencies: Effectiveness of Epipen and Anapen - Are they Fit for Purpose - Evidence to Date
TLDR
It is surprising that there are currently no internationally accepted criteria, including International Organization of Standards or other governmental regulatory requirements to benchmark the performance of adrenaline auto-injectors under standard conditions as there are for insulin pen injectors.
Anaphylaxis treatment: current barriers to adrenaline auto‐injector use
TLDR
The aim of this review is to highlight the barriers that exist to the use and availability of AAIs and that prevent proper management of anaphylaxis and discuss the need for regulatory requirements to establish the performance characteristics of these devices.
The Past, the Present and the Future of Epinephrine Autoinjectors
TLDR
In the present review, development process and ideal features of adrenalin autoinjectors; the effects of design of autoin injectors on its proper use, and current progressions in theautoinjector technology are discussed in the light of published reports.
Comparison of adrenaline auto‐injector devices: Ease of use and ability to recall use
  • M. Robinson, S. Dharmage, M. Tang
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2014
TLDR
A limited number of adrenaline auto‐injectors are currently available and few studies have compared the performance of these devices.
A simple method to improve safety of epinephrine auto‐injectors
TLDR
Training this sequence, with industry-provided trainer devices, will prevent erroneous injections into hand and fingers in patients as well as caregivers and may help epinephrine injectors to fulfill the recently published criteria for the ‘ideal’ device.
Managing vaccine‐associated anaphylaxis in the pharmacy
TLDR
An emerging role for appropriately credentialed pharmacists in Australia is the administration of vaccines to adults, and Pharmacists administering vaccinations must be adequately prepared and competent to act should anaphylaxis occur within the community pharmacy setting.
Update on the usage and safety of epinephrine auto-injectors, 2017
TLDR
Overall, it is believed that the benefits of using EAIs far outweigh the potential risks of not administering an EAI, and continued training of medical providers, caregivers, and patients may be beneficial to address concerns and reduce EAI-associated injuries.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 75 REFERENCES
Anaphylaxis to foods
  • G. Roberts
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2007
Three crucial areas of the management of anaphylaxis due to food allgery are discussed: making a diagnosis, deciding who needs a self‐injectable adrenaline device and spotting the novel allgern.
The role of epinephrine in the treatment of anaphylaxis
TLDR
Patients with known anaphylactic reactivity should be prescribed an epinephrine auto-injector to be carried at all times for treatment of potential recurrences and education of the patient or parent regarding the proper use of this tool is paramount.
Self-injectable epinephrine for allergic emergencies.
TLDR
The technique for self-injectable epinephrine administration in allergic emergencies is reviewed, including discussion of the available dosages and formulations, indications, as well as other issues related to its use.
Adrenaline in the treatment of anaphylaxis: what is the evidence?
TLDR
The safety and efficacy of adrenaline in the treatment of anaphylaxis in the light of currently available evidence is discussed, and a pragmatic approach to use of adrenaline auto-injectors is suggested.
Lessons for management of anaphylaxis from a study of fatal reactions
  • Pumphrey
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2000
The unpredictability of anaphylactic reactions and the need for immediate, often improvised treatment will make controlled trials impracticable; other means must therefore be used to determine
Practical allergy (PRACTALL) report: risk assessment in anaphylaxis
TLDR
Improved methods for distinguishing between allergen sensitization and clinical risk of anaphylaxis were deliberated and innovative techniques that will improve risk assessment in anaphYLaxis in the future were described.
Self-injectable Epinephrine for First-Aid Management of Anaphylaxis
TLDR
Although it is certainly not unreasonable to prescribe self-injectable epinephrine for children with cutaneous-only reactions to insect stings, it can also be quite reassuring to patients and caregivers that the chances of a more severe reaction are, in fact, very small.
Knowledge about using auto-injectable adrenaline: review of patients' case notes and interviews with general practitioners
TLDR
Because referred patients' (or their parents’) knowledge about using these devices was poor at the first visit to the clinic, the knowledge of local general practitioners was assessed.
When should self-injectible epinephrine be prescribed for food allergy and when should it be used?
  • R. Pumphrey
  • Medicine
    Current opinion in allergy and clinical immunology
  • 2008
TLDR
The fallibility of autoinjectors means that in the management of food allergy, their provision must take second place to accurate identification of the trigger foods, optimal avoidance, and optimal treatment of other medical conditions that make reactions more dangerous.
Epinephrine: The Drug of Choice for Anaphylaxis--A Statement of the World Allergy Organization
TLDR
Epinephrine is currently underused and often dosed suboptimally to treat anaphylaxis, is underprescribed for potential future self-administration, and most of the reasons proposed to withhold its clinical use are flawed, but the therapeutic benefits of epinephrine exceed the risk when given in appropriate intramuscular doses.
...
1
2
3
4
5
...