Corpus ID: 228083453

What Were They Thinking? Pharmacologic priors implicit in a choice of 3+3 dose-escalation design

@article{Norris2020WhatWT,
  title={What Were They Thinking? Pharmacologic priors implicit in a choice of 3+3 dose-escalation design},
  author={David C Norris},
  journal={arXiv: Methodology},
  year={2020}
}
  • David C Norris
  • Published 2020
  • Mathematics, Biology, Psychology
  • arXiv: Methodology
If explicit, formal consideration of clinical pharmacology at all informs the design and conduct of modern oncology dose-finding trials, the designs themselves hardly attest to this. Yet in conducting a trial, investigators affirm that they hold reasonable expectations of participant safety - expectations that necessarily depend on beliefs about how certain pharmacologic parameters are distributed in the study population. Thus, these beliefs are implicit in a trial's presumed conformance to a… Expand

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