What H.M. Taught Us

@article{Eichenbaum2013WhatHT,
  title={What H.M. Taught Us},
  author={Howard Eichenbaum},
  journal={Journal of Cognitive Neuroscience},
  year={2013},
  volume={25},
  pages={14-21}
}
  • H. Eichenbaum
  • Published 2013
  • Psychology, Biology
  • Journal of Cognitive Neuroscience
Studies on H.M. generated five main findings: that memory is a distinct psychological function, that amnesia spares short-term and working memory, that amnesia is an impairment of declarative and episodic memory, that the hippocampus is a core brain structure supporting memory, and that the hippocampus supports the permanent consolidation of memories. Each of these basic findings has recently been challenged, but a consideration of these studies suggests the new observations serve to support… 
Classic and recent advances in understanding amnesia
  • R. Allen
  • Psychology, Biology
    F1000Research
  • 2018
TLDR
Debate continues regarding the patterns of preservation and impairment across a range of abilities, including semantic memory and learning, delayed recognition, working memory, and imagination, and some of the influential and recent advances in these debates are highlighted.
Evaluating Hippocampal Contributions
TLDR
This chapter explores possible contributions made by the hippocampus to perception, short-term or working memory, and expressions of memory in the absence of conscious awareness.
Dynamic Hippocampal Circuits Support Learning- and Memory-Guided Behaviors.
TLDR
Key findings from the laboratory are summarized, with a focus on recent discoveries that indicate that the rat hippocampus supports learning and decision-making behaviors via dynamic and smooth transitions in neural representation, internal processing state, and coupling with related brain structures.
Beyond Long-Term Declarative Memory: Evaluating Hippocampal Contributions to Unconscious Memory Expression, Perception, and Short-Term Retention
TLDR
This chapter reviews literature that points to a role for the hippocampus in three additional domains—namely, perception, short-term or working memory, and unconscious expressions of memory—and suggests that the reach of the hippocampus extends well beyond long-term declarative memory.
When does conscious memory become dependent on the hippocampus? The role of memory load and the differential relevance of left hippocampal integrity for short- and long-term aspects of verbal memory performance
TLDR
The results indicate an increasing correspondence between the integrity of the left hippocampus and verbal memory with an increasing long-term memory component.
Thanks for the Memories …
HOW DOES MEMORY WORK? It turns out that there is one brain structure that appears to be a ‘memory maker’. Without it, we cannot remember anything that has happened to us, even from only a few minutes
Representational Account of Memory: Insights from Aging and Synesthesia
TLDR
This work investigated how the disparate sensory-perceptual abilities between these groups translated into associative memory performance for visual stimuli that do not induce synesthesia, and provided novel evidence for the direct contribution of perceptual mechanisms to visual associatives memory.
Cognitive neuroscience methodologies provide insight into medial temporal lobe contributions to perception, language, and creativity
TLDR
Functional magnetic resonance adaptation (fMRa) is used to show that brain structures in the visual processing stream can bind item features prior to the involvement of hippocampal binding mechanisms, and to track complex object representations in perirhinal cortex.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 69 REFERENCES
Memory, amnesia, and the hippocampal system
TLDR
A cognitive neuroscience theory of memory is offered that accounts for the nature of memory impairment exhibited in human amnesia and animal models of amnesia, that specifies the functional role played by the hippocampal system in memory, and that provides further understanding of the componential structure of memory.
Memory consolidation, retrograde amnesia and the hippocampal complex
What's new with the amnesic patient H.M.?
  • S. Corkin
  • Psychology
    Nature Reviews Neuroscience
  • 2002
H.M. became amnesic in 1953. Since that time, nearly 100 investigators, first at the Montreal Neurological Institute and since 1966 at the Massachusetts Institute of Technology, have participated in
The Long and the Short of It: Relational Memory Impairments in Amnesia, Even at Short Lags
TLDR
Evidence is found for hippocampal involvement in relational memory, even at short lags normally considered the province of working memory.
Schemas and Memory Consolidation
TLDR
It is reported that systems consolidation can occur extremely quickly if an associative “schema” into which new information is incorporated has previously been created.
Recognition memory and the medial temporal lobe: a new perspective
TLDR
The methods traditionally used to separate recollection from familiarity instead separate strong memories from weak memories, and it is suggested that these structures work together in a cooperative and complementary way.
Impaired Recognition Memory in Monkeys after Damage Limited to the Hippocampal Region
TLDR
The finding that the hippocampal region is essential for normal recognition memory performance is considered in the context of current ideas about the role of the hippocampus in declarative memory.
From Conditioning to Conscious Recollection Memory Systems of the Brain. Oxford Psychology Series, Volume 35.
TLDR
The neurobiological properties of dedicated and elaborate systems to their neuropsychological counterparts are related, and in so doing, account for the phenomenology of memory, from conditioning to conscious recollection.
Hippocampus Cognitive Processes and Neural Representations that Underlie Declarative Memory
...
1
2
3
4
5
...