What Does Potency Actually Mean for Inhaled Corticosteroids?

  title={What Does Potency Actually Mean for Inhaled Corticosteroids?},
  author={Dennis Williams},
  journal={Journal of Asthma},
  pages={409 - 417}
Inhaled corticosteroids (ICSs) are the most effective anti-inflammatory agents currently available for the treatment of persistent asthma, irrespective of severity [1-5]. Although the potential for... 
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Comparative studies of inhaled corticosteroids in asthma.
The lack of statistical significant differences between the two preparations is proposed to indicate that the efficacy of inhaled corticosteroids delivered through different inhaler devices via standard CFC-containing preparations in current use is likely to be similar.
Efficacy and Safety of Inhaled Corticosteroids in Asthma
Inhaled steroids are now used at a much earlier stage in asthma therapy, and there is a strong argument for their early introduction in both adults and children to prevent asthma morbidity and mortality and possibly the structural changes resulting from uncontrolled chronic inflammation.
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It is difficult to draw firm conclusions with respect to the therapeutic index of different inhaled corticosteroids because no direct placebo-controlled, dose-response comparisons of clinical effects have been made, but available studies suggest that microgram for microgram, when delivered by a pressurized metered-dose inhaler, fluticasone propionate is more effective than beclomethasone dipropionate.
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Papers with subject headings or an abstract in English were included and Abstracts from scientific sessions from the American Journal of Respiratory and Critical Care Medicine, the Journal of Allergy and Clinical Immunology, Thorax and the European Respiratories Journal between 1993 and 1997 were searched.
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In randomized, controlled clinical trials, inhaled corticosteroids, as monotherapy, are superior to other therapies in improving lung function and clinical outcomes in patients with asthma, however, the use of inhaling these agents is limited by concerns of dose‐related adverse effects, including growth suppression and decreased bone density.
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The objective of the Asthma Committee was to suggest a model that could be tested through a National Study and, if data were insufficient to do this, determine what other studies should be conducted.
Comparison of Inhaled Corticosteroids
  • H. Kelly
  • Medicine
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The preponderance of current data suggests that the existing inhaled corticosteroids have similar risks of producing systemic effects when administered in equipotent antiinflammatory doses as a metered-dose inhaler plus spacer or as their respective dry-powder inhaler.
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The respiratory care practitioner should be aware that estimating the clinical benefits from the topical anti-inflammatory effects of these newer products will be difficult to determine from information made available about the relative advantages and disadvantages of these new products.
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Dose-response relationships were not disproportionately driven by the highest doses, and the greatest effects on response were seen at doses below or at the low end of the recommended range, suggesting that use of high doses of ICS may contribute only marginally to efficacy.
A comparison of the efficacy and safety of inhaled corticosteroids in asthma
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