What's new with the amnesic patient H.M.?

  title={What's new with the amnesic patient H.M.?},
  author={Suzanne Corkin},
  journal={Nature Reviews Neuroscience},
  • S. Corkin
  • Published 1 February 2002
  • Psychology
  • Nature Reviews Neuroscience
H.M. became amnesic in 1953. Since that time, nearly 100 investigators, first at the Montreal Neurological Institute and since 1966 at the Massachusetts Institute of Technology, have participated in studying him. We all understand the rare opportunity we have had to work with him, and we are grateful for his dedication to research. He has taught us a great deal about the cognitive and neural organization of memory. We are in his debt. 
The cognitive neuroscience of human memory since H.M.
Focus is placed on the neuroanatomy of medial temporal lobe and diencephalic structures important for memory, multiple memory systems, visual perception, immediate memory, memory consolidation, the locus of long-term memory storage, the concepts of recollection and familiarity, and the question of how different medialporal lobe structures may contribute differently to memory functions.
The Legacy of Patient H.M. for Neuroscience
What H.M. Taught Us
  • H. Eichenbaum
  • Psychology, Biology
    Journal of Cognitive Neuroscience
  • 2013
A consideration of these studies suggests the new observations serve to support the original findings on H.M. and improve the understanding of the memory functions of the hippocampal system.
HM: A Legacy in Neuroscience
  • Erik Eckbo
  • Medicine
    McGill Science Undergraduate Research Journal
  • 2009
During the 1930s, Penfield developed the surgical treatment of epilepsy by means of temporal lobe resection, and this procedure became a standard among many neurosurgical centres.
The Famous Memories of a Famous Amnesic
The current findings are the first in five decades of study to report substantive and unmistakable postmorbid declarative learning in patient H.M.M and support the connection that has been argued to exist between the specialized anatomy and plasticity of the hippocampus and the uniqueness of episodic memory.
The medial temporal-lobe amnesic syndrome.
  • B. Milner
  • Psychology, Biology
    The Psychiatric clinics of North America
  • 2005
The case of K.C.: contributions of a memory-impaired person to memory theory
The amnesias.
Memory impairment resulting from damage to the medial temporal lobe, diencephalon, basal forebrain, and the frontal lobes is elaborated, with a focus on MTL amnesia, which has received the most attention among memory researchers.


Normal McCollough effect in Alzheimer’s disease and global amnesia
A dissociation between learning mechanisms that mediate recall and recognition versus mechanisms thatMediate the McCollough effect is demonstrated, consistent with other sources of evidence implicating early visual areas, especially V1, as a critical locus of the ME.
Memory. Autopsy findings and comments on the role of hippocampus in experiential recall.
The cases of two patients who had suffered a grave and totally unexpected loss of recent memory as the result of partial left temporal lobectomy in treatment of focal epilepsy are published.
Recognition memory: What are the roles of the perirhinal cortex and hippocampus?
This work focuses on the central issue in this dispute — the relative contributions of the hippocampus and the perirhinal cortex to recognition memory.
Diminished ability to interpret and report internal states after bilateral medial temporal resection: case H.M.
It is believed that the bilateral resection of the amygdala accounts for H.M.'s poor appreciation of his internal states and his impairment is not attributable to his well-documented memory deficit.
H.M. Revisited: Relations between Language Comprehension, Memory, and the Hippocampal System
The results bear on two general classes of theories in use within a wide range of neurosciences and cognitive sciences: the data favor fidistributed-memory theoriesfl that ascribe H.M.'s deficit to semantic-level binding processes that are inherent to both language comprehension and memory, over fistages-of-processing theories, where H.m.'s defective storage processes have no effect on language comprehension.
Memory consolidation, retrograde amnesia and the hippocampal complex
H.M.'s Language Production Deficits: Implications for Relations between Memory, Semantic Binding, and the Hippocampal System ☆ ☆☆ ★
Present results contradict stages of processing theories that localize H.M.M.'s deficit to a storage stage that is independent of processes for retrieving and producing verbal materials, and instead support a distributed-memory theory in which memory storage and retrieval involving verbal materials are inherent aspects of normal language production.
Memory deficit produced by bilateral lesions in the hippocampal zone.
The following study shows that the capacity to record the daily current of conscious experience may be lost when there is bilateral destruction of a man's hippocampus and hippocampal gyrus.
Differential effects of early hippocampal pathology on episodic and semantic memory.
Global anterograde amnesia is described in three patients with brain injuries that occurred in one case at birth, in another by age 4, and in the third at age 9. Magnetic resonance techniques