What's new in atopic eczema? An analysis of systematic reviews published in 2010–11

@article{Torley2013WhatsNI,
  title={What's new in atopic eczema? An analysis of systematic reviews published in 2010–11},
  author={Donna Torley and Masaki Futamura and Hywel C. Williams and Kim Suzanne Thomas},
  journal={Clinical and Experimental Dermatology},
  year={2013},
  volume={38}
}
This review provides a summary of key findings from 24 systematic reviews of atopic eczema (AE) published or indexed between 1 August 2010 and 31 December 2011, updating published summaries from previous years. Epidemiological evidence points to the protective effects of early daycare, endotoxin exposure, consumption of unpasteurized milk, and early exposure to dogs, but antibiotic use in early life may increase the risk for AE. With regard to prevention of AE, there is currently no strong… 
What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 2. Treatment and prevention
TLDR
There is now clear evidence that evening primrose oil and borage oil are not effective for the treatment of AE, and the most promising intervention for the prevention of AE is the use of probiotics during the late stages of pregnancy and early life.
What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 2. Treatment and prevention
TLDR
Although no benefit was found for allergen avoidance in preventing AE, the use of immunotherapy to treat AE‐associated aeroallergen sensitivity requires further evaluation and there is insufficient evidence for Vitamin D supplementation for the treatment of AE.
What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 1. Epidemiology, mechanisms of disease and methodological issues
TLDR
There is now reasonable evidence to suggest that antibiotic exposure in early life is associated with increased incidence of AE, but delivery by caesarean section is not, and a standardized definition of an incident case of AE for use in prevention studies is still required.
What's new in the topical treatment of allergic skin diseases
TLDR
There is strong evidence for the use of topical anti-inflammatory therapies in the treatment of atopic dermatitis and there is little evidence to suggest that one emollient is better than others.
Atopic Dermatitis: An Evidence-Based Treatment Update
  • J. Silverberg
  • Medicine
    American Journal of Clinical Dermatology
  • 2014
TLDR
Investigator-initiated RCTs support the use of the systemic agents cyclosporine, methotrexate, azathioprine and mycophenolate mofetil, and in one RCT, petrolatum was found to be as effective as creams containing ceramides or glycyrrhetinic acid.
An overview of drug discovery efforts for eczema: why is this itch so difficult to scratch?
TLDR
Drug discovery efforts for AD are reviewed, highlighting the clinical efficacy of novel drugs, with a particular focus on the relief of pruritus, as well as topical PDE4 inhibitors and subcutaneous dupilumab, which are safe and efficacious.
Triggers in atopic dermatitis/eczema : separating fact from fiction : review article
TLDR
An overview will be given regarding the relevant literature dealing with triggers of atopic dermatitis/eczema, which includes irritants, allergens, skin infections and others, including cigarette smoke exposure and psychological stress.
Environmental Risk Factors for Development of Atopic Dermatitis: a Systematic Review
TLDR
A systematic review found significant risk of development of AD in genetically susceptible children with environmental risk factors of maternal atopy, environmental pollutants, food allergy, and early antibiotic exposure.
Is the alternative medicine a real alternative in adult atopic dermatitis? Experiences of 125 patients
TLDR
Most of the adult patients have unsatisfying experiences with the vast majority of the tried AT in the therapy of AD symptoms, and both the high number of patients trying these methods and the inefficient attempts are noteworthy.
...
...

References

SHOWING 1-10 OF 44 REFERENCES
What’s new in atopic eczema? An analysis of systematic reviews published in 2009–2010
TLDR
This review provides a summary of key findings from 18 systematic reviews on atopic eczema, published or indexed between January 2009 and 24 August 2010, which found no evidence of a benefit from any form of antistaphylococcal treatment in managing clinically infected or uninfected Eczema.
What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 1. Epidemiology, mechanisms of disease and methodological issues
TLDR
There is now reasonable evidence to suggest that antibiotic exposure in early life is associated with increased incidence of AE, but delivery by caesarean section is not, and a standardized definition of an incident case of AE for use in prevention studies is still required.
What’s new in atopic eczema? An analysis of systematic reviews published in 2007 and 2008. Part 2. Disease prevention and treatment
TLDR
Clinical important findings from systematic reviews indexed in bibliographical databases between August 2007 and August 2008 that dealt with disease prevention and treatment of atopic eczema are summarized.
What’s new in atopic eczema? An analysis of the clinical significance of systematic reviews on atopic eczema published in 2006 and 2007
TLDR
The evidence suggests that avoidance of allergenic foods during pregnancy or the use of hydrolyzed or soy formula milks does not prevent Eczema, and delayed introduction of solids may decrease eczema risk.
What’s new in atopic eczema? An analysis of systematic reviews published in 2007 and 2008. Part 1. Definitions, causes and consequences of eczema
This review summarizes clinically important findings from nine systematic reviews indexed in bibliographical databases between August 2007 and August 2008, dealing with the definitions, causes and
What's new in atopic eczema?
TLDR
The review aims to summarize the most recent findings of more innovative treatment approaches such as modulation of cytokines or chemokines, modulation of T-cell responses or anti-IgE therapy.
Association between domestic mould and mould components, and asthma and allergy in children: a systematic review
TLDR
It is suggested that home environments with visible mould and mould spore exposure increase the risk of allergic respiratory health outcomes in children, and research should focus on specific microbial markers in the home, in combination with new assessment techniques including molecular methods.
Atopic dermatitis and the hygiene hypothesis revisited.
TLDR
Evidence is found for an inverse relationship between helminth infections and AD but no other pathogens and future studies should assess skin barrier gene mutation carriage and phenotypic skin barrier impairment, as gene-environment interactions are likely to impact on AD risk.
A systematic review of tacrolimus ointment compared with corticosteroids in the treatment of atopic dermatitis
TLDR
A systematic review and meta-analysis showed tacrolimus ointment to be of similar efficacy to corticosteroids and the interpretation of available data is limited by heterogeneity in outcome measures between trials.
An evidence-based review of the efficacy of coal tar preparations in the treatment of psoriasis and atopic dermatitis.
TLDR
Most studies support the use of coal tar products, although their level of evidence is not strong, and Coal tar products appear to be therapeutic in psoriasis and AD, are well tolerated with few side effects, and are cost-effective.
...
...