What’s new in autism?

  title={What’s new in autism?},
  author={Jean Steyaert and Wouter De la Marche},
  journal={European Journal of Pediatrics},
This review on autism spectrum disorder (ASD) focusses on recent insights in the clinical picture, such as continuity of the phenotype and the concept of broader phenotype, on epidemiology and on clinical issues relevant to physicians, including new methods for early screening and diagnosis, psychiatric and somatic co-morbidity, and the expansion of so-called complementary and alternative treatments. ASD is a disorder with mainly genetic causes and recent insights show that a variety of genetic… 

Update on autism: A review of 1300 reports published in 2008


Due to the large heterogeneity of identi†ed changes in the genome of individuals with ASDs, the newest techniques enabling analysis of the entire genome in one study (microarrays, next-generation sequencing) are the methods of choice in the diagnostics of this pathology.

Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder

It is proposed that future studies examining shared familial etiological factors for ADHD and ASD use a family-based design in which the same phenotypic (ADHD and ASD), candidate endophenotypic, and environmental measurements are obtained from all family members.

The Path to Diagnosis: A Case Study of Two Children with Autism

After reviewing the case studies of two families with children who have been diagnosed with autism, there are many similarities found that may account for the rise in diagnosis of autism.

Association between Autism Spectrum Disorder and Iron Deficiency in Children Diagnosed Autism Spectrum Disorder in the Northern West Bank

It was found that the frequency of low iron intake in these children was associated with feeding difficulties and food selectivity, and it was suggested that ferritin levels should be measured in children with autism as a part of routine investigation.

Immune dysregulation in autism spectrum disorder

The perinatal environment generates vulnerability to chronic neuro-inflammation in the brain associated with profound modulation and dysregulation in the immune system leading to the rapid development of ASD in genetically susceptible children.

Temporality of Risk Factors and the Gender Differential Related to Autism Spectrum Disorder Diagnosis

Temporality of Risk Factors and the Gender Differential Related to Autism Spectrum Disorder Diagnosis by Donna L. Sullivan MBA, Saint Louis University, 1993 MS, University of Minnesota, 1990 BA,

Autism and X-linked hypophosphatemia: A possible association?

Reports of cases with the joint occurrence of a known genetic syndrome and a diagnosis of ASD by a child psychiatrist are relevant because there are a number of arguments countering a causal link.

Autism as the Early Closure of a Neuroplastic Critical Period Normally Seen in Adolescence.

The role of a shortened period of neuroplasticity as a unifying feature of the autistic phenotype is examined, allowing for neural integration and the development of language and social skills.



Clinical genetics evaluation in identifying the etiology of autism spectrum disorders

The guidelines in this article have been developed to assist the clinician in the consideration of a host of different factors, including an accurate diagnosis of autism before proceeding with any investigation and an individualized evaluation scheme based on the unique history and clinical features of a given patient.

The genetics of autism.

Significant evidence is found for multiple interacting genetic factors as the main causative determinants of autism and for interactions between multiple genes cause "idiopathic" autism but that epigenetic factors and exposure to environmental modifiers may contribute to variable expression of autism-related traits.

The neurobeachin gene is disrupted by a translocation in a patient with idiopathic autism

In a group of 525 subjects with autism who were karyotyped and had no recognised underlying medical condition, four were found to carry such a de novo chromosomal aberration, and the identification of genes involved in autism is expected to increase the understanding of the pathogenesis of this disorder.

On the selection of patients with developmental delay/mental retardation and autism spectrum disorders for genetic studies

  • A. Battaglia
  • Medicine
    American journal of medical genetics. Part A
  • 2007
Standards for defining DD/MR/ASD should be just as stringent as the authors' standards for defining molecular break points in cytogenetic reports—stating acquisition of selected developmental milestones, or lack thereof, is not sufficient.

Informative phenotypes for genetic studies of psychiatric disorders

  • P. SzatmariM. Maziade R. Palmour
  • Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2007
The different types of informative phenotypes that can be employed in psychiatric genetic studies are described to clarify their uses, to identify several methodologic issues the design and conduct of linkage and association studies that use alternative phenotypes and finally to suggest possible solutions to those difficulties.

Diagnosis and Epidemiology of Autism Spectrum Disorders

  • L. TidmarshF. Volkmar
  • Psychology, Medicine
    Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 2003
An overview of the diagnostic categories of autism and other pervasive developmental disorders (PDDs) is given and the changes in the DSM classification system over the past 20 years are discussed.

Autism spectrum disorder in the second year: stability and change in syndrome expression.

The study provides support for stability of clinical diagnosis and syndrome expression in the second year and highlights advantages and limitations of the ADI-R and ADOS-G for diagnosing and documenting symptoms of ASD in infants.

Novel treatments for autistic spectrum disorders.

  • S. LevyS. Hyman
  • Psychology, Medicine
    Mental retardation and developmental disabilities research reviews
  • 2005
Secretin as a therapy for autism is discussed as an example of how a clinical observation rapidly grew to a widespread treatment before well-designed studies demonstrated absence of effect.

Epilepsy in autism spectrum disorders

  • R. Canitano
  • Psychology, Medicine
    European Child & Adolescent Psychiatry
  • 2006
The current understanding of the association between epilepsy and autism is still limited, but from a clinical point of view this association should not be overlooked, and it should be routinely investigated.

Is autism an autoimmune disease?