What's the damage? The impact of pathogens on pathways that maintain host genome integrity.

@article{Weitzman2014WhatsTD,
  title={What's the damage? The impact of pathogens on pathways that maintain host genome integrity.},
  author={Matthew D Weitzman and Jonathan B. Weitzman},
  journal={Cell host & microbe},
  year={2014},
  volume={15 3},
  pages={283-94}
}
Maintaining genome integrity and transmission of intact genomes is critical for cellular, organismal, and species survival. Cells can detect damaged DNA, activate checkpoints, and either enable DNA repair or trigger apoptosis to eliminate the damaged cell. Aberrations in these mechanisms lead to somatic mutations and genetic instability, which are hallmarks… CONTINUE READING