Corpus ID: 199455836

What's new in the management of acne vulgaris.

  title={What's new in the management of acne vulgaris.},
  author={Leon H. Kircik},
  volume={104 1},
Drug development continues to focus on the challenge of treating acne effectively and safely. Inflammation is a backdrop to the commonly cited elements of the pathophysiology of acne: Propionibacterium acnes proliferation, increased sebum production with an increase in circulating androgens, and faulty keratinization. As such, there is increased emphasis on targeting inflammation and its effects. Vehicle innovations are optimizing existing active drugs and creating opportunities to deliver new… Expand
4 Citations
Fighting acne for the fighting forces.
A case in which the pulsed dye laser (PDL) was successfully used to treat inflammatory acne in an active-duty servicemember is presented to highlight the use of PDL as an available and effective treatment option for acne in this population. Expand
An overview of sarecycline for the treatment of moderate-to-severe acne vulgaris
Sarecycline is a novel, tetracycline-class antibiotic specifically designed to treat inflammatory acne. It offers a narrow spectrum of activity (mainly against Cutinebacterium acnes), and it shows ...
Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases
Well-balanced nutrition and additional anti-inflammatory PUFA-based supplementation should be encouraged in a targeted manner for individuals in need to provide better management of skin diseases but, most importantly, to maintain and improve overall skin health. Expand
Complete Draft Genome Sequence of Cutibacterium (Propionibacterium) acnes Type Strain ATCC6919
The complete genome sequence of Cutibacterium acnes type strain ATCC6919 is reported, which provides a valuable reference for comparative analysis based on the genomic characteristics and resistance gene diversity of C. acnes. Expand


[Pathophysiology of acne].
This finding provides physiological support to the clinical observation that stress can induce acne, as it was once thought that only the androgens could stimulate the seba-ceous gland, but today it is known that neuromediators can also stimulate sebum production. Expand
Guidelines of care for the management of acne vulgaris.
Issues from grading of acne to the topical and systemic management of the disease are reviewed and suggestions on use are provided based on available evidence. Expand
Tazarotene foam, 0.1%, for the treatment of acne
The foam vehicles may increase compliance and satisfaction in some patients and as retinoids are commonly first line acne treatments, this new topical retinoid foam may be a useful option for some acne patients. Expand
Assessment of etiologic agents in acne pathogenesis.
The environment within the pilosebaceous unit is probably more important than the absolute number of P. acnes organisms, and the major role of the sebaceous gland appears to be supplying P. Acnes needed nutrients. Expand
Anti‐inflammatory effects of tetracyclines
  • M. Schaller
  • Medicine
  • Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2017
Treating study patients with doxycycline was not inferior to standard treatment with oral prednisolone for short-term blister control but significantly safer in the longer term, and several groups could show that subantimicrobial dose doxy cycline used to treat parodontitis seems to have no effect on composition or resistance levels of the microflora. Expand
Minocycline for acne vulgaris: efficacy and safety.
Although minocycline was shown to be an effective treatment for moderate to moderately-severe acne vulgaris, there was no evidence that it is better than any of the other commonly-used acne treatments. Expand
Efficacy and Safety of Sarecycline, a Novel, Once-Daily, Narrow Spectrum Antibiotic for the Treatment of Moderate to Severe Facial Acne Vulgaris: Results of a Phase 2, Dose-Ranging Study.
Sarecycline was safe and well tolerated, with similar gastrointestinal AE rates in sarecycline and placebo groups, and may lead to less selective pressure on enteric Gram-negative bacteria, resulting in less disruption of commensal organisms and less potential for antibiotic resistance. Expand
Minocycline: far beyond an antibiotic
A review will cover the most important topics in the pharmacology of minocycline to date, supporting its evaluation as a new therapeutic approach for many of the diseases described herein. Expand
The Use of Hormonal Antiandrogen Therapy in Female Patients with Acne: A 10-Year Retrospective Study
HAAT usage is associated with shorter cumulative antibiotic durations and early HAAT initiation can decrease systemic antibiotic use in acne treatment, which is not typically used as a first-line systemic therapy in women with acne. Expand
A novel topical minocycline foam for the treatment of moderate‐to‐severe acne vulgaris: Results of 2 randomized, double‐blind, phase 3 studies
FMX101 4% topical minocycline foam significantly reduced both inflammatory and noninflammatory lesions and improved Investigator's Global Assessment scores in patients with moderate‐to‐severe acne. Expand